The Pharmacokinetics of Paracetamol

1 November 2017

A paracetamol tablet
                                                  won't hurt
you; it will alleviate
                                                  your aches.
That white tablet’ll
                                                  move down
your GIT and swiftly
                                                  disintegrate.
Within an hour, it’ll
                                                  virtually all
be absorbed into the
                                                  bloodstream.
                                                                                     The [paracetamol]-

                                                                                                                                  time plot will


                                                                                                                                                                reach its max


                                                                                                                                                      then


                                                                                                                                  drop by half-


                                                                                                                        lives.


                                                                                     The area under


                                                                           the


                                                  curve will


                                   then


capture the drug’s
                                                  kinetics.
Particles will’ve gone
                                                  through fine
branches straight into
                                                  most tissues.
This paracetamol
                                                  won't hurt
you; it will alleviate
                                                  your aches.
It will metabolise
                                                  in your liver
to produce inactive
                                                  metabolites.
The chemicals will
                                                  move between
two compartments:
                                                  blood & urine.
                                                                                     The [metabolite]-

                                                                                                                                  time plot will


                                                                                                                                                                reach its max


                                                                                                                                                      then


                                                                                                                                  drop by half-


                                                                                                                        lives.


                                                                                     The area under


                                                                           the


                                                  curve will


                                   then


capture metabolic
                                                  kinetics.
Within a day, it’ll
                                                  virtually all
be excreted via the
                                                  urinary tract.
There will be nary
                                                  a trace of the
paracetamol left in
                                                  your system.
Your pain will’ve
                                                  become
a distant memory.




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